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Wang, Q.-X./ L. Bao/ X.-L. Yang/ H. Guo/ R.-N. Yang/ B. Ren/ L.-X. Zhang/ H.-Q. Dai/ L.-D. Guo/ H.-W. Liu 2012: Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp.. - Fitoterapia 83(1): 209-214. [RLL List # 226 / Rec.# 33736]
Keywords: Antimicrobial/ Endolichenic fungus/ Polyketides/ Radical scavenging activities/ Ulocladium sp./ 5' methoxy 6 methyl biphenyl 3,4,3' triol/ 6 hydroxy 8 methoxy 3a methyl 3a,9b dihydro 3h furo[3,2 c]isochromene 2,5 dione/ 6 o methylnorlichexanthone/ 7 hydroxy 3 (2 hydroxy propyl) 5 methyl isochromen 1 one/ 7 hydroxy 3, 5 dimethyl isochromen 1 one/ altenuene/ altenusin/ alterlactone/ amphotericin B/ antifungal agent/ antiinfective agent/ ascorbic acid/ dihydroaltenuene/ fungal extract/ gentamicin/ griseoxanthone c/ isoaltenuene/ norlichexanthone/ polyketide/ rubralactone/ scavenger/ unclassified drug/ vancomycin/ antifungal activity/ antioxidant activity/ article/ Aspergillus fumigatus/ Bacillus subtilis/ Candida albicans/ controlled study/ drug isolation/ drug structure/ Escherichia coli/ fungus/ fungus culture/ IC 50/ lichens/ methicillin resistant Staphylococcus aureus/ nonhuman/ nuclear magnetic resonance/ priority journal/ Pseudomonas aeruginosa/ racemic mixture/ ulocladium/ Bacillus subtilis/ Candida albicans SC5314/ Fungi/ methicillin resistant Staphylococcus aureus/ Ulocladium
Abstract: Two new polyketides, 7-hydroxy-3, 5-dimethyl-isochromen-1-one (1) and 6-hydroxy-8-methoxy-3a-methyl-3a,9b-dihydro-3H-furo[3,2-c]isochromene-2,5-dione (2), along with eleven known compounds, 5?-methoxy-6-methyl-biphenyl-3,4, 3?-triol (3), 7-hydroxy-3-(2-hydroxy-propyl)-5-methyl-isochromen-1-one (4), rubralactone (5), isoaltenuene (6), altenuene (7), dihydroaltenuenes A (8), altenusin (9), alterlactone (10), 6-O-methylnorlichexanthone (11), norlichexanthone (12), and griseoxanthone C (13) were isolated from the culture of the endolichenic fungus Ulocladium sp. Compound 2 was obtained as a racemate with an unprecedented chemical skeleton. The NMR data assignments for 3 and 4 were achieved for the first time. Compounds 1-13 were screened for their antimicrobial and radical scavenging activities. Compound 1 showed some antifungal activity against Candida albicans SC 5314 with IC50 of 97.93 ± 1.12 ?M. Compounds 11-13 showed strong activity against Bacillus subtilis with IC50 in the range of 1-5 ?M. Compound 12 significantly inhibited the growth of methicillin-resistant Staphylococcus aureus with IC50 of 20.95 ± 1.56 ?M. Compounds 9 and 10 showed strong radical scavenging activity in comparison with vitamin C. The plausible biosynthetic pathways for compounds 1, 2, and 4-8 were discussed. Crown Copyright © 2011 Published by Elsevier B.V. All rights reserved.
URL: http://dx.doi.org/10.1016/j.fitote.2011.10.013
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