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Behera, B.C./ Morey, M.V./ Gaikwad, S.B. 2016: Anti-lipoxygenase, radical scavenging and antimicrobial activities of lichen species of genus Heterodermia (Physciaceae). - Botanical Pacifica 5(1): 79-85. [RLL List # 244 / Rec.# 38050]
Abstract: The aim of the research is to explore antilipoxygenase, radical scavenging and antimicrobial activity of the ethyl acetate extract of the selected lichen species of genus Heterodermia (Physciaceae). The species extract have shown concentration dependent lipoxygenase (LOX) inhibition. Fifty percent (IC50) LOX inhibition was obtained by H. diademata, H. flabellata, H. antillarum and H. incana with 0.123, 0.153, 0.160, 0.150 mg/ml respectively; which is smaller than the synthetic antioxidant BHA and BHT. Only the extract of H. diademata showed IC50, 0.123 mg/ml is equal to LOX inhibitor Indomethicin. The LOX inhibition kinetics with respect to the lichen extract resulted different mode of inhibition. Competitive inhibition was found towards LOX by H. albicans, H. antillarum; uncompetitive inhibition by H. diademata and noncompetitive inhibition showed by H. angustiloba, H. flabellata, H. incana, H. isidiophora and H. pseudospeciosa. These species extract have also showed ≤50 % radical scavenging activity. The ethyl acetate extract of H. diademata, H. angustiloba, H. albicans and H. isidiophora showed the strong antimicrobial activity against most of the tested microorganisms at concentration ranging from 0.232 mg/ml to 0.591 mg/ml. These findings suggest that these lichen species of genus Heterodermia can be used as new bioresources for the natural lipoxygenase inhibitor with antimicrobial and radical scavenging features.
URL: http://www.geobotanica.ru/bp/2016_05_01/behera_2016.html
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