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Micheletti, A. C./ N. K. Honda/ D. P. Lima/ A. Beatriz/ M. R. Sant'ana/ N. C. P. Carvalho/ M. De Fatima Cepa Matos/ L. M. M. Queiróz/ D. Bogo/ J. R. Zorzatto 2011: Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines. - Quimica Nova 34(6): 1014-1020. [RLL List # 224 / Rec.# 33204]
Keywords: Antimicrobial activity/ Cytotoxic activity/ Xanthone
Abstract: A series of 15 ?aminoalkoxylxanthones containing methyl, ethyl, propyl, tert-butylamino and piperidinyl moieties were synthesized from a natural xanthone isolated from a lichen species. These compounds were tested for their in vitro antibacterial properties against Gram-positive and Gram-negative bacteria and cytotoxicity against a number of human tumor cell lines was too evaluated. The newly synthesized derivatives revealed selective activity against Staphylococcus aureus (Gram-positive), and the most promising results are for a multidrug resistant strain, for which six of these compounds showed good activity (MICs 4 µg/mL). Many derivatives inhibited tumor cells growth and most compounds were active on multiple lines.
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